![]() The Japan Diabetes Complications Study (JDCS)/the Japanese Elderly Diabetes Intervention Trial (J-EDIT) risk engine (JJ risk engine) was developed in Japan in 2012. ![]() This risk engine was developed using Japanese patient data therefore, it is expected that its prediction accuracy will be higher for Japanese subjects than for Western subjects. The JJ Risk Engine accurately predicts macro- and micro-vascular complications and provides useful information for risk classification and health economic simulations. ![]() The algorithm of this risk engine uses the multi-state Cox regression model. However, since 2012 when the JJ risk engine was developed, diabetes treatment policies have changed significantly. Before 2010, a high premium was placed on decreasing blood sugar levels while treating diabetes, making it difficult to avoid hypoglycemia. Moreover, since 2010, hypoglycemia, particularly severe hypoglycemia, has become a recognized risk factor for the development of coronary heart disease (CHD). ![]() With the announcement of the “Kumamoto Declaration 2013,” the diabetes treatment policy has changed to one that emphasizes the prevention of hypoglycemia. Accordingly, the use of antidiabetic drugs that are less likely to cause hypoglycemia has increased. ![]()
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